Glemid – 5


Glemid Tabs. This brand product contains glibenclamide 5mg tablet which belongs to a class known as Sulfonylureas. It is used to control blood glucose level in patients with type 2 diabetes mellitus in conjunction with diet control and exercise.

During short-term treatment, glibenclamide increases insulin secretion from functioning pancreatic islet β-cells (pancreatic effect) whereas during long-term treatment its main action appears to be enhancements of insulin action on peripheral tissues and reduction of glucose outpost from liver (extrapancreatic effects).


Clinical Pharmacology

Non-steroidal anti-inflammatory agents and other drugs that are highly protein bound, as salicylates, sulfonamides, chloramphenicol, probenecid, coumarin derivates, beta-adrenergic blocking agents, ACE inhibitors, anabolic steroids, fenfluramine, miconazole, phenylbutazone, fluoxetine, biguanide preparations reserpine, PAS, tetracyclines are known to potentiate hypoglycaemic in patients under treatment with glibenclamide.
Chronic alcoholism and chronic abuse of laxatives may lead to deterioration of the control of diabetes.

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Other Info

Treatment with glibenclamide is usually started with a single daily dose of 5 mg in the morning but in the elderly or those with significant renal impairment, the initial dose should be reduced to 2.5 mg or even 1.25mg daily. If blood glucose level is not adequately controlled after 2 to 4 weeks, the daily dose is increased by 2.5 mg- 5 mg at similar intervals until satisfactory glycaemic control has been reached. The total daily dose may be taken with or half an hour before breakfast; daily doses exceeding 10 mg may also be divided into a morning and an evening dose taken with meals.