This combo kit is an ideal drug combination for the eradication of Helicobacter pylori as recommended by the MACH 1 study utilizing the optimum dose of clarithromycin in the PPI, Clarithromycin and Tinidazole (PCT) regimen. A published study of this combination puts its H. pylori eradication rate at 93.1%. The inclusion of tinidazole in Helikit makes it better tolerated with enhanced compliance compared with most other preparations with metronidazole. It is very convenient as only three pills are taken twice daily and not four as may be commonly found.



Clinical Pharmacology

Helicobacter pylori are probably the most common bacterial infection with a worldwide prevalence of approximately 50% Helicobacter pylori is implicated in the etiology of gastritis and peptic ulceration in humans. Conventional histamine-2 receptor antagonists do not suppress or eradicate Helicobacter pylori and have a high rate of ulcer recurrence. Monotherapy using bismuth compounds or antimicrobials is not very effective with an eradication rate, not more than 15-20%. Dual therapy with bismuth salt plus antimicrobials agent eradicates Helicobacter pylori in only 50%of cases.

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Other Info

Clarithromycin has good in vitro activity (MIC90 Value 0.03mg/l against H. pylori, which makes it suitable for incorporation into the regimen for the eradication of H. pylori infection.
Tinidazole 5-nitroimidazole is more potent and long-acting compared to metronidazole. It is active against protozoal and anaerobic bacterial infection. Tinidazole is considered to be an active anti-microbial agent against H.pylor and exerts rapid bactericidal actions. Tinidazole acts by damage of DNA strands or inhibition of their synthesis.