Notopain

Description

Notopain is for relief from severe pain and inflammation in Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis. Low back pain, Dental pain, Gynaecological pain, painful & Inflammatory conditions of ear, nose & throat. Each caplet contains Diclofenac Sodium BP 50mg Paracetamol BP 500mg.
Dosage and Administration
The maximum recommended dose of NOTOPAIN is two caplets daily, as one caplet in the morning and one in the evening.

Contraindications

  • Patients sensitive to paracetamol or to any of the excipients of the product
  • Patients in whom aspirin or other NSAIDs precipitate attacks of bronchospasm, acute rhinitis or urticaria or patients hypersensitive to these drugs.
  • Patients with active or suspected peptic ulcer or gastrointestinal bleeding or bleeding disorders
  • Patients with severe heart failure, hypertension, hepatic or renal insufficiency,
  • Third trimester of pregnancy

 

Clinical Pharmacology

Diclofenac relieves pain and inflammation through a variety of mechanisms and in addition, exerts stimulatory effects on cartilage matrix synthesis.
Anti-inflammatory activity: the anti-inflammatory effects of Diclofenac have been shown in both acute and chronic inflammation. It inhibits various mediators of pain and inflammation including:
• PGE2 via cyclooxygenase inhibition (COX-1 & COX-2) after intracellular metabolism to 4’hydroxy-aceclofenac and diclofenac in human rheumatoid synovial cells and other inflammatory cells.
• IL-IB, IL-6 and tumor necrosis factor in human osteoarthritic synovial cells and human articular chondrocytes.
• Reactive oxygen species (which plays a role in joint damage) has also been observed in patients with osteoarthritis of the knee.
• Expression of cell adhesion molecules (which is implicated in cell migration and inflammation) has also been shown in human neutrophils.

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NAFDAC No

B4-1961

Other Info

Analgesic action: The central analgesic action of paracetamol resembles that of aspirin. It produces analgesia by raising pain threshold.
Antipyretic effects: The antipyretic effect of paracetamol is attributed as its ability to inhibit COX in the brain where peroxide tone is low.
Recent evidence suggests inhibition of COX-3 (believed to be splice varient product of the COX-1 gene) could represent primary central mechanism by which paracetamol decreases pain and possibly fever.